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KMID : 1141020190190010073
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Journal of Applied Oriental Medicine
2019 Volume.19 No. 1 p.73 ~ p.86
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Effect of Cassia semen on Lipid Metabolism in High-fat Diet-induced Dyslipidemia Mouse Model
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Baek Seon-Jae
Roh Seong-Soo
Park Ji-Ha
Koo Jin-Suk
Seo Bu-Il
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Abstract
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Objectives : Dyslipidemia has recently become an important social burden for public health. Therefore, the aim of this study was to investigate improvement effects of Cassia semen (CS) on dyslipidemia mouse model induced by high-fat diet.
Methods : The antioxidant activity and the inhibitory effect of pancreatic lipase were evaluated by in vitro assays. Experimental animals were divided into 3 groups; Control group, CS200 group and CS400 group. All groups were supplied high-fat diet for inducing dyslipidemia. During the experimental period, CS200 group and CS400 group were administrated CS extract at dose of 200 and 400 mg/kg/day, respectively. The changes of reactive oxygen species (ROS), peroxynitrite (ONOO-), triglyceride (TG), total cholesterol (TC), High-density lipoprotein cholesterol (HDL-C) and Low-density lipoprotein cholesterol (LDL-C) in serum were analyzed.
Results : The antioxidant capacity of CS was evaluated and its IC50 were 25.91 ㎍/㎖ for DPPH and 54.41 ㎍/㎖ for ABTS. Total phenol and total flavonoid of CS were 35.89 and 35.38 ㎎/g, respectively. Also, CS inhibited pancreatic lipase activity in a concentration-dependant manner. In dyslipidemia mouse model, the administration of CS was decreased body weight gain and the weight of epididymal fat. Moreover, CS administration suppressed the levels of ROS, ONOO-, TG, TC, and LDL-C in serem. On the contraty, serum HDL-C level was increased by CS administration.
Conclusion : In conclusion, these results support that CS may possess a therapeutic effect on dyslipidemia via antioxidant activity and pancreatic lipase inhibitory activity.
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KEYWORD
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Cassia semen, Dyslipidemia, Lipid metabolism, Pancreatic lipase, Antioxidant
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